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Shintaro Horie, Mitsunao Ide, Kei Morohoshi, Kyoko Ohno-Matsui; Evaluation of En-face OCT Images in Diabetic Macular Edema with Anti-VEGF Treatment. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2110.
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© ARVO (1962-2015); The Authors (2016-present)
In diabetic macular edema (DME), en-face OCT presents two-dimensional distribution of microcysts, which intuitively indicates severity of the disease. In this study, utility of area measured by en-face OCT was examined comparing with the other factors in sectional OCT.
17 eyes of 14 DME patients in our outpatient clinic (Tokyo Medical and Dental University Hospital), who were given anti-VEGF therapy (either Ranibizumab or Aflibercept) and en-face OCT examination (RTVueXR Avanti®) from March 2015 to November 2015, were included. Data obtained from clinical records and OCT images were retrospectively examined. The area of DME was measured by en-face OCT (3mm square). The central or maximum retinal thickness was measured by sectional swept-source OCT (Topcon Atlantis®). Correlation analysis was performed within the areas of macular edema, central retinal thickness and maximum retinal thickness.
The area of DME measured by en-face OCT was significantly correlated with central retinal thickness by sectional OCT (p<0.0001). When comparing before and after administrations of the anti VEGF drugs, the alteration of area and that of maximum retinal thickness were significantly related (p=0.011). In this study, the comparison between the Ranibizumab treated and the Aflibercept treated group showed no significant differences in those factors.
En-face OCT is useful for clinical management of DME not only it give us intuitive two-dimensional pathology but also it is related to other conventional factors in sectional OCT. Utilizing en-face OCT in the assessment of therapeutic effects is also hopeful.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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