Abstract
Purpose :
Changes in choroidal circulation with improvement of acute central serous chorioretinopathy (CSC) by photocoagulation (PC) remain unknown. The aim of this study was to evaluate changes in choroidal blood flow velocity by using laser speckle flowgraphy (LSFG) in patients with acute CSC.
Methods :
Six eyes of 6 acute CSC patients (5 men, 1 woman; mean age, 49.5 years) were treated by PC. LSFG measurements and subfoveal choroidal thickness (CT) measurements by enhanced depth imaging optical coherence tomography were taken before and 1 month after PC to the leaking spot. LSFG measurements were performed to calculate macular mean blur rate (MBR).
Results :
Subretinal fluid decreased at 1 month after PC and completely resolved within 2 months after PC. Macular MBR of CSC eye was significantly decreased to 84.0 ± 11.4 % (p = 0.019, paired t-test) at 1 month after PC, whereas that of the fellow eye was 111.1 ± 15.2 % (p = 0.133), against baseline (100%). CT of CSC eye was significantly decreased from 360 ± 61 µm to 84.0 ± 11.4 µm (p = 0.001) at 1 month after PC, whereas there was no decrease of CT in the fellow eye (from 332 ± 85 µm to 340 ± 85 µm, p = 0.098).
Conclusions :
PC treatment for acute CSC decreased macular choroidal blood flow velocity and central choroidal thickness, suggesting that elevation of choroidal blood flow is involved in pathogenesis of CSC.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.