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Sung Min Kim; Measurable Range of Subfoveal Choroidal Thickness with Conventional Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2180.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the measurable range of subfoveal choroidal thickness (SFCT) with conventional spectral domain optical coherence tomography (SD OCT) in normal healthy eyes.
Imaging data and clinical records of study subjects were evaluated. All subjects underwent SD OCT horizontal line scan centered at the fovea with both standard and enhanced depth imaging (EDI) techniques. Two independent observers manually measured SFCT in standard and EDI OCT images, if 2 choroidal borders were identified. Eyes were classified into 5 thickness groups, according to the SFCT measured by EDI OCT. The measurement rate with standard OCT, and the intra- and interclass correlation coefficient of measured SFCT between 2 OCT methods were evaluated.
OCT images of total 724 normal healthy eyes from 374 sujects were evaluated. Although the inner choroidal border was identified on all OCT images, the outer choroidal border was identified on all EDI OCT images, and on 378 of 724 (52.2%) conventional OCT images. Mean SFCT of EDI OCT images was 292.6 ± 94.0 um (range, 41 - 555 um), and interclass correlation coefficient was 0.995 (p<0.001). The number of successful measurements with conventional OCT was 221/221 (100%), 77/88 (87.5%), 62/129 (48.1%), 18/114 (15.8%), and 0/172 (0%), in the SFCT range of <241 um, 241-280 um, 281-320 um, 321-360 um, and >360 um, respectively. The accumulated rate of successful measurement with conventional OCT was 100% (221/221), 96.4% (298/309), and 82.2% (360/438) in the SFCT range of ≤240 um, ≤280 um, and ≤320 um, respectively. Mean SFCT of conventional OCT images was 223.9 ± 63.0 um (range, 41-358 um) and interclass correlation coefficient was 0.977 (p<0.001). In eyes having SFCT measured by both EDI and conventional OCT, intraclass correlation coefficient between the 2 OCT methods was 0.997(p<0.001).
Subfoveal choroidal thickness can be measured by conventional OCT in eyes with thin choroid, and the measured value shows high agreement with those measured by EDI OCT. In such eyes, conventional OCT can potentially be used to evaluate both retina and choroid.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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