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Nallely Ramos Betancourt, Josué David Rodríguez-Pedraza, Abelardo Rodríguez-Reyes, Francisco Beltrán-Díaz De La Vega, Alfredo Terán-Tejada, Everardo Hernandez-Quintela; Epidemiology of Ocular Surface Squamous Neoplasia in an Ophthalmology Center in Mexico City. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2401. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the clinical and histologic characteristics of Ocular Surface Squamous Neoplasia (OSSN) and to provide epidemiologic data of this disease in a referral Ophthalmology Center in Mexico City.
The records of the Department of Ocular Pathology from 2005 to 2015 were reviewed. The search included corneal and/or conjunctival specimens containing the following terms as diagnosis: "papilloma", "actinic", "dysplasia", "intraepithelial neoplasia", "carcinoma in situ", "squamous cell carcinoma", or "invasive carcinoma". A total of 241 specimens from 241 patients were identified. Only initial biopsies were included. Pathology reports and corresponding clinical records were reviewed for patient age and gender, involved eye, location of the lesion, self-reported progression time, presumptive and definitive diagnosis, tumor grade, presence at surgical margins, corneal or intraocular invasion, mytotic activity and recurrence. Statistical analysis was performed using SPSS V. 22.
Mean age of patients was 58.6 years old (+/-20.8), and 136 (56.4%) were male. Left eye was affected in 126 cases (52.3%). Of 241 specimens included, 51 (21,2%) were classified as CIN. Five (2,1%) were grade I, 18 (7.5%) were grade II and 28 (11,6%) grade III. Invasive squamous carcinoma was identified in 48 cases (19,9%). Actinic keratosis without atypia was 2,5% of all cases (6) and with atypia 13,7% (33). The most frequent lesion was papilloma (103 cases, 42,7%).
In our Center, almost half of the lesions were associated with Human Papilloma Virus. Most of CIN were classified between stage II to III, and invasive squamous carcinoma was a frequent lesion, encountered up to 20%.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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