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Sang Yeop Lee, Tyler Hyungtaek Rim, Hee Jung Kwon, Hyoung Won Bae, Chan Yun Kim; Increased Stroke Risk among Patients with Open-Angle Glaucoma: A 10-Year Follow-up Cohort Study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2615.
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© ARVO (1962-2015); The Authors (2016-present)
Although several studies showed the correlation between the stroke and open angle glaucoma (OAG), there have not been enough large population based longitudinal studies. In this study, we investigated the risk of subsequent stroke development after initial OAG diagnosis over a 10-year follow-up period.
We performed a retrospective nationwide propensity score-matched cohort study. OAG and comparison groups were selected from a large database from the Korean National Health Insurance Service, comprising 1,025,340 random subjects. The OAG group comprised patients with an initial diagnosis of OAG between January 2004 and December 2007 (n = 1,520), and the comparison group comprised randomly selected patients (five per glaucoma patient; n = 7,570). Patients who were diagnosed with stroke before the enrollment date were excluded. Each cohort was tracked until 2013 for stroke development. Cox proportional hazard regression analysis was performed to determine possible association.
OAG was associated with increased stroke incidence (HR = 1.20). Hypertension, diabetes mellitus, chronic renal failure, atrial fibrillation, hyperlipidemia, increasing age, and male gender also increased the incidences of stroke. Risk of stroke for OAG patients was greater in the older age group (≥ 65 years, HR = 1.23) than in the younger age group (< 65 years, HR = 1.12), and greater in males (HR = 1.31) than in females (HR = 1.10).
Patients who were diagnosed with OAG were more likely to experience subsequent stroke than comparison groups without OAG, and the risk was greater for older adults and males.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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