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Kiyoung Kim, Sang Youl Rhee, Hyung-Woo Kwak, Suk Chon, Jeong-taek Woo, Seung-Young Yu; Analysis of Genetic and Environmental risk factors associated with diabetic retinopathy, diabetic macular edema and neurodegeneration in Korean diabetes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2648.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate association of genetic and environmental factors of diabetic retinopathy (DR), diabetic macular edema (DME) and retinal nerve fiber layer (RNFL) thickness in Korean diabetes patients
183 Korean patients with type 2 DM from Kyung Hee University Hospital, Seoul, completed ophthalmic exams using fundus photography and optical coherence topography (Cirrus OCT) for segmented retinal layer thickness. Individuals are categorized according to the DR grade (no DR, NPDR, PDR) and presence of DME. Clinical characteristics including blood chemistry, past medical and social history information was collected with standardized questionnaires. Genotype association and logistic regression analyses were done and stepwise regression models to best predict diabetic retinopathy and DME were constructed
Age, microalbumin, BUN, Cr, dyslipidemia, daily activity were significantly associated factor with DR (all P<0.05). Age, weight, diastolic pressure, HbA1c, microalbumin and liver function profile were significantly associated factor with DME (all P<0.05). Specific single nucleotide polymorphisms (SNPs) showed significant association with DR, DME and RNFL thinning, which needs further confirmation with replication cohort
There were several significant environmental and biological risk factors for Korean DR and DME patients. All of found genes are possibly involved with DR, DME and retinal neurodegeneration respectively. This finding nominates possible novel loci as potential DR susceptibility genes in the Korean that are independent biochemistry factors and may provide further insight into the pathophysiology of DME and retinal neurodegneration, known as early change of DR
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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