September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Sleep disorders in dry eye disease and allied irritating ocular diseases
Author Affiliations & Notes
  • Masahiko Ayaki
    Keio University, Tokyo, Japan
  • Motoko Kawashima
    Keio University, Tokyo, Japan
  • Kazuno Negishi
    Keio University, Tokyo, Japan
  • Taishiro Kishimoto
    Keio University, Tokyo, Japan
  • Masaru Mimura
    Keio University, Tokyo, Japan
  • Kazuo Tsubota
    Keio University, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Masahiko Ayaki, None; Motoko Kawashima, None; Kazuno Negishi, None; Taishiro Kishimoto, None; Masaru Mimura, None; Kazuo Tsubota, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 2840. doi:
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    • Get Citation

      Masahiko Ayaki, Motoko Kawashima, Kazuno Negishi, Taishiro Kishimoto, Masaru Mimura, Kazuo Tsubota; Sleep disorders in dry eye disease and allied irritating ocular diseases. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2840.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate sleep disorders in patients with dry eye disease (DED) and allied irritating ocular diseases.

Methods : This is a cross-sectional and case-control study and seven hundred and fifteen outpatients diagnosed with DED, chronic conjunctivitis, or allergic conjunctivitis across six eye clinics were initially enrolled. Of these, 301 patients with DED and 202 age-matched control participants with other ocular surface diseases were analyzed. The Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) were evaluated.

Results : The mean PSQI and HADS scores were 6.4 ± 3.2 and 11.1 ± 5.7 for severe DED (n = 146), 5.5 ± 3.3 and 9.8 ± 4.0 for mild DED (n = 155), 5.5 ± 3.1 and 9.5 ± 6.6 for chronic conjunctivitis (n = 124), and 5.0 ± 3.3 and 8.9 ± 5.3 for allergic conjunctivitis (n = 78). There were significant differences among these diagnostic groups for PSQI (P < 0.05). Regression analysis of patients with DED revealed the PSQI and HADS scores were significantly correlated with the severity of DED (P < 0.05).

Conclusions : Sleep quality in patients with DED was significantly worse than in patients with other irritating ocular surface diseases and it was correlated with the severity of DED. The present results suggest the quality of life in patients with DED may be exacerbated by sleep disorders. Psychiatric treatment focusing on sleep disorders could therefore beneficial for these patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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