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Yoshifumi Okamoto, Sujin Hoshi, Mikki Arai, Genichiro Kishino, Fumiki Okamoto, Tetsuro Oshika; The effect of intraoperative application of chemically defined bioadhesive powder for trabeculectomy in rabbit eyes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):2954.
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© ARVO (1962-2015); The Authors (2016-present)
A newly developed chemically defined bioadhesive (CDB) which is made from dextran and poly lysine is used to prevent postoperative tissue adhesion. CDB contains no animal-derived ingredients made from antibiotic food additives and its safety has been confirmed. The purpose of this study was to investigate the effect of CDB powder to prevent postoperative tissue adhesion in trabeculectomy.
Three rabbit eyes with α chymotrypsin induced glaucoma underwent trabeculectomy. A 3x3 mm scleral flap was made following fornix based conjunctival incision. CDB powder was applied under the conjunctiva and scleral flap, and was gelled by dripping the balanced salt solution. The scleral flap and conjunctiva were closed with 10-0 nylon water-tightly. No mitomycin-C (MMC) or other agents were used. Slit-lamp examination, intraocular pressure (IOP) measurement, and anterior segment optical coherence tomography (AS-OCT) were carried out at 7 days, 1 and 2 months postoperatively.
No significant inflammation and infection were observed in all eyes with slit-lamp examination throughout the follow-up period. IOP was significantly reduced by surgery during the study period. AS-OCT imaging showed successful bleb formation up to 2 months postoperatively in every operated eye.
The new CDB powder may be effective to inhibit conjunctival and scleral adhesion after trabeculectomy without MMC.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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