September 2016
Volume 57, Issue 12
ARVO Annual Meeting Abstract  |   September 2016
Age-related changes in aqueous humor dynamics in healthy Chinese adults
Author Affiliations & Notes
  • tao guo
    ophthalmology, Shanghai ninth people's hospital,Shanghai JiaoTong University School of Medicine, ShangHai, China
    ophthalmology, Shanghai Tenth people's hospital, ShangHai, China
  • Footnotes
    Commercial Relationships   tao guo, None
  • Footnotes
    Support  This study was sponsored by the Shanghai municipal commission of health and family plan fund (20124100)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3045. doi:
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      tao guo; Age-related changes in aqueous humor dynamics in healthy Chinese adults. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3045. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To investigate how aging affects aqueous humor dynamics of healthy Chinese adults.

Methods : In this prospective, observational controlled single center study: 33 subjects between 20 and 30 years of age and 37 subjects aged 50 years and older agreed to participate. All measurements were obtained between 8 AM and 3 PM on one study day. Intraocular pressure (IOP) was measured by pneumatonometry and noncontact tonometry, tonographic outflow facility (Cton) by pneumatonography, and episcleral venous pressure (EVP) by venomanometry. Aqueous flow and outflow facility were determined by fluorophotometry. Uveoscleral outflow (Fu) was calculated by using the Goldmann equation. Anterior chamber depth and central cornea thickness (CCT) were obtained by ultrasound pachymetry. Results from the two age groups were analyzed by SPSS19- mixed model- line method.

Results : When comparing the older group with the younger group, the central cornea was thinner (531±37 versus 550±27 μm; P=0.019); axial length (25.2 ± 1 vs 23.3 ± 1 mm; P < 0.001); anterior chamber volume decreased (130±34 versus 216±31 μL; P=0.000); Fa was less (2.67±0.78 versus 3.05±0.73 μl/min; p=0.008); and Fu slowed (0.74±1.03 versus 1.00±1.14 μl/min; p=0.273). Episcleral venous pressure, outflow facility and IOP were not different between groups.

Conclusions : As healthy Chinese adults age, the anterior chamber volume becomes smaller due in part to shortening of axial length and potentially to thickening of the lens. Aqueous humor is produced at a slower rate and drained through the uveoscleral pathway at a similarly slow rate. These changes keep IOP effectively unchanged over decades.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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