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Anna Sala-Puigdollers, Javier Zarranz-Ventura, Marc Figueras-Roca, Mireia Hereu, Teresa Hernandez, Montserrat Morató, Marina Mesquida, Victor Llorens, Maria Teresa Sainz de la Maza, Alfredo Adan Civera; Repeatability and reproducibility of retinal and choroidal thickness measurements in Diabetic Macular Edema using Swept-source Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3268.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the repeatability and reproducibility of retinal and choroidal thickness measured with Swept source Optical Coherence Tomography (SS-OCT) in eyes with Diabetic Macular Edema (DME).
42 eyes of 25 patients with macular edema secondary to diabetes mellitus were imaged using SS-OCT standard Macular scanning protocols. Retinal and choroidal thickness were measured in the Early Treatment Diabetic Retinopathy Study (ETDRS) grid Total macular circle (TMC) and foveal central subfield (FCS) using device-integrated specific software. The coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were determined as a measure of repeatability and relative reliability within graders. Reproducibility was assessed using Bland-Altman plots and 95% limits of agreement (LoA) as a measure of interobserver variability.
Intragrader CR of retinal and choroidal thickness were 8.37 and 12.20 microns for TMC and 22.24 and 32.40 microns for FCS respectively, and intergrader 95% LoA were 7.37 - 8.69 and -27.2 - 27.71 microns for TMC and -34.21 - 41.93 and -30.46 - 24.84 for FCS, respectively. Retinal and choroidal thickness showed very good intraobserver reliability for both TMC (ICC 0.99, LoA 0.99-0.99, and ICC 0.99, LoA 0.99-0.99) and FCS (ICC 0.99, LoA 0.99-0.99, and ICC 0.99, LoA 0.98-0.99). Interobserver variability for retinal and choroidal thickness measurements was not significantly different for TMC (p=0.30, p=0.17) or FCS (p=0.07, p=0.20).
Retinal and choroidal thickness in DME eyes can be quantified with good reliability, repeatability and reproducibility using new OCT devices that incorporate swept source technology. The longer wavelength of the laser source allows greater penetration of the laser beam in the retinal tissue and better visualization of deeper structures, which may provide new insights in the understanding of the choroidal changes related with DME.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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