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Laura Vickers, Handan AKIL, Elmira Baghdasaryan, Olivia L Lee; Measurement of Iris Lesion Volume with Anterior Segment Swept-Source Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3386.
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© ARVO (1962-2015); The Authors (2016-present)
To calculate the volume of iris lesions using anterior segment swept-source optical coherence tomography (OCT) to enhance the clinical assessment of lesions, with comparison to the gold standard ultrasound biomicroscopy (UBM).
Two eyes of two patients with iris lesions underwent imaging with anterior segment swept-source OCT (Casia SS-1000, Tomey, Nagoya, Japan) as well as ultrasound biomicroscopy (Ellex Eyecubed 40 MHz UBM, Ellex medical Pty. Adelaide, Australia). Image processing software ImageJ (U. S. National Institutes of Health, Bethesda, Maryland, USA) was used to calculate the iris lesion volume from the 3-dimensional (3D) gonioscopic reconstruction of the OCT images. Lesion volume as calculated from the OCT was compared to lesion height as measured by UBM.
One iris lesion, a clinically diagnosed iris melanoma, measured 5.7 mm in greatest circumference and 5.5 µL volume. The second iris lesion, clinically diagnosed as a large cyst, involved both the ciliary body and iris, measuring 15.4 mm greatest circumference and 76.0 µL volume.
Anterior segment OCT with 3D gonioscopic reconstruction can be used to calculate the volume of iris lesions. This may be used for clinical monitoring of lesions including change in size over time. Future studies of a greater number of eyes over time will compare sensitivity of OCT versus UBM for detection of change in size of iris lesions.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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