Abstract
Purpose :
To study the prognostic effect of peripheral retinal non-perfusion on macular thickness and visual acuity in diabetic and venous occlusive retinopathies.
Methods :
156 and 53 treatment naive eyes with diabetic (88% NPDR and 12% PDR) and venous occlusion (40% BRVO, 13% HRVO and 47% CRVO) retinopathies, respectively, were randomly selected from our practice between August 2008 and August 2014. Wide-field retinal funds photos and fluorescein angiography (FA) were obtained on all patients using the Optos 200 Tx system (Optos plc, Scotland, UK). The peripheral perfusion index (PI), which was defined as the area beyond 45 degrees, was calculated using ImageJ 1.43 software. Student t-tests and regression analyses were used to analyze the data.
Results :
47% of DR and 55% of RVO subjects showed significant linear correlation between % peripheral and central non-perfusion. Ignoring peripheral non-perfusion misses ≈50% of total non-perfusion. In NPDR, macular thickness and central non-perfusion statistically affected VA. The average extent of peripheral non-perfusion was 2.2x fold larger in RVO compared to DR (8.8% RVO vs. 3.9% DR). In RVO, the effect of peripheral non-perfusion on VA was 2x folds significantly larger than that of macular thickness.
Conclusions :
Peripheral non-perfusion sheds potential prognostic insights in vaso-occlusive retinopathies. In the future, peripheral non-perfusion could potentially be included in vaso-occlusive retinopathies' disease staging in order to enhance guided treatment options.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.