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Francisco Pérez Bartolomé, Jose María Martínez de la Casa, Irene Camacho Bosca, Federico Sáenz Francés, Julián García Feijoó; Correlating corneal biomechanical properties with lamina cribosa in healthy subjects.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3550. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To examine interrelations between corneal biomechanics, ocular biometric variables and optic disc size (ODS), lamina cribosa depth (LCD) or thickness (LCT) in a healthy population.
In a cross sectional case-control study, the following measurements were made in 56 eyes of 56 participants: axial length, anterior chamber depth, lens thickness and central corneal thickness using the optical biometer Lenstar LS900; and corneal hysteresis, corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) using the ocular response analyzer. Serial horizontal enhanced depth imaging optical coherence tomography (EDI OCT) B- scans of the optic nerve head were obtained in each participant. Mean ODS, mean LCD and mean LCT were measured in 11 equally-spaced horizontal B- scans, excluding the LC insertion area under Bruch's membrane and scleral rim.
Data for 40 eyes were available for statistical analysis. LCD was greater in men than women by a mean of 45.34 ± 19.88 µm (95% CI 5.092 - 85.58 µm; P= 0.028; Student's t). LCT was directly correlated with ODS (r= 0.331; P= 0.042). Corneal biomechanical properties and ocular biometrics variables were poorly (non-significantly) correlated with LCD, LCT and ODS.
Insufficient evidence was detected to indicate significant correlation between corneal biomechanical properties or ocular biometric variables and ODS, LCD or LCT.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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