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Kara Marie Cavuoto, Korey Jaben, Ta Chen Chang; Progression in infantile glaucoma: comparing structural and biometric changes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3554. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
The detection of progression in infantile glaucoma is based on clinical impressions of optic nerve and axial length changes. However, the sensitivity, specificity and relation to intraocular pressures of these changes are unknown. The purpose of our study was to evaluate the frequency of optic nerve and axial length changes in uncontrolled infantile-onset glaucoma.
Retrospective masked grading of disc photos, review of axial lengths and review of medical records of children with infantile glaucoma who failed angle surgery and medical management prior to age of three years.
56 examinations of 16 eyes (14 patients) were included. Axial length changes (greater than 30% of expected value) and disc changes from baseline occurred in 51.8% and 33.9% of examinations, respectively. In the subgroup with intraocuar pressure less than 20 mmHg, 16.7% and 5.6% demonstrated progression by axial length and disc changes, respectively.
In infantile glaucoma patients who have failed angle surgery and medical therapy, progressive pathologic axial length changes occur more frequently than optic disc changes. These changes can occur even when the intraocular pressure is under 20 mmHg.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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