September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal study of retinal and optic nerve function in patients with multiple sclerosis – a baseline report
Author Affiliations & Notes
  • Christina Gerth-Kahlert
    University of Zurich, Zurich, Switzerland
  • Klara Landau
    University of Zurich, Zurich, Switzerland
  • James VM Hanson
    University of Zurich, Zurich, Switzerland
  • Footnotes
    Commercial Relationships   Christina Gerth-Kahlert, None; Klara Landau, None; James Hanson, Biogen (R)
  • Footnotes
    Support  JVMH is partially funded by the Clinical Research Priority Program of the University of Zurich
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3603. doi:
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      Christina Gerth-Kahlert, Klara Landau, James VM Hanson; Longitudinal study of retinal and optic nerve function in patients with multiple sclerosis – a baseline report. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3603.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To assess in detail retinal and optic nerve function using electrophysiological methods in patients with newly diagnosed relapsing-remitting multiple sclerosis (RRMS).

Methods : Patients diagnosed with MS with or without a history of optic neuritis (ON) or other ocular manifestation are included in this prospective longitudinal study. Each patient received a comprehensive eye examination. The following functional tests were performed: scotopic and photopic fullfield (ff) ERG according to ISCEV standards, photopic negative response (PhNR) of the flash ERG, photopic mfERG (61 and 103 hexagons), pattern-reversal VEP. Data were compared with age- matched normal controls.

Results : Baseline examination data will be presented of patients recruited at the time of the meeting. So far, 24 patients (17 female, 7 male) ages 21 to 57 years were tested. 14/24 had a history of ON in one (10/14) or both (4/14) eyes. Abnormal responses were found: scotopic and photopic ffERG: 1/24, photopic ffERG: 6/24, reduced PhNR through 5/24, unilateral VEP 9/23, bilateral VEP 8/23, delayed mfERG responses 7/23.

Conclusions : Patients with MS demonstrate retinal and optic nerve dysfunction related or unrelated to the history of NNO. Extended electrophysiological testing allows detailed functional assessment to possibly characterize distinct phenotypes of MS.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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