Abstract
Purpose :
To investigate the impact of intravitreal chemotherapy on intraocular pressure in children with retinoblastoma.
Methods :
Retrospective study of ten eyes of ten retinoblastoma patients (7 males, 3 females, mean age 33.6 ± 9.4 months) with vitreous seeding injected with intravitreal melphalan and topotecan. Intraocular pressure (IOP) was measured with Tonopen at baseline prior to injecting and then repeatedly following each intravitreal injection.
Results :
Mean pre-injection IOP was 8.2 ± 2.3 mm Hg (range 4.0 – 12.0 mm Hg). Mean IOP 1-30 seconds after intravitreal melphalan (first injection) was 45.4 ± 14.3 mm Hg. 89.5% of patients declined to ≤ 29 mm Hg in a mean 153.3 ± 97.5 seconds. Mean IOP 1-30 seconds after intravitreal topotecan (second injection) was 44.5 ± 11.0 mm Hg and decreased to 31.0 ± 5.0 by 150 seconds after injection. No significant relationship was found between age and post-injection IOP elevation. IOP exceeded calculated mean arterial perfusion pressure in four encounters.
Conclusions :
Intravitreal chemotherapy caused a transient rise in IOP. Post-injection IOP elevations can reach levels that may exceed mean arterial pressure.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.