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chaim Stolovitch; Home use binocular dichoptic video content treatment for amblyopia-pilot study. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
To assess home use device for treatment of Amblyopia using dynamically altered dichoptic presentation of video contents without patching.
25 subjects,age 4-8 years,with refractive/strabismic or combined amblyopia,with visual acuity ≤ 20/50 in the amblyopic eye were enroled prospectively.The device used software that dynamically alters any video content dichoptically,using video goggles,in which reduced contrast of the content is presented to the good eye. All the children had best corrected refraction glasses for at least 3 months prior to treatment and were reluctant for further patching or using atropine. All were instructed to use the device for 30-60 min daily,viewing passively child/animated TV shows at home without patching.Visual Acuity was assessed at baseline and after 4,8 and 12 weeks of treatment.VA was assesed in 15 and 12 patients at week 24 and week 36 respectively after termination of treatment .Visual acuity was measured with M&S VA computerized system and the results were transformed and expressed in logMar unit.Statistical analysis was done using Wilcoxon T-test related samples.
17 patients completed 8 weeks of treatment and 16 patients 12 weeks.Base line Mean VA in the amblyopic eye was 0.648 (±0.1898).At 4 week visit,mean VA improved significantly to 0.46 (0.1828 ± 0.1443 lines) in the amblyopic eye(P=0.0004), at 8 weeks visit mean VA improved to 0.394(0.254 ± 0.1.687 lines,P=0.000437) and at 12 weeks to 0.386(0.2582 ± 0.1853 lines,P=0.00098) from base line VA.15 patients were examined after cessation of treatment at week 24 with a very small change in mean VA -0.12 line(P=0.575) from Last mean VA measurments at week 12.12 patients return for last visit at week 36 with very small detrioration of mean VA:-0.086 line(P=0.0593) from mean VA at week 12 which was not statisticaly significant.8 patients completed 4 weeks of Sham protocol with no improvement (mean change in VA of amblyopic eye 0.0063 ±0.1653,P=0.4226) from base line VA. Compliance was excellent:100% of the reccommended time and even up to 110% in some kids who would not stop viewing their favorite movies.
Passive viewing of dynamically altered dichoptic presentation of any video content achieved very good results at 4 weeks of treatment with further improvement after 8 week without patching.The improvement sustained for at least 6 months.It has the potential to be used as treatment for Amblyopia.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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