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Naoko Aizawa, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa; Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3900. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate visual field defect region and its deterioration speed in preperimetric glaucoma (PPG).
This study is a prospective observational study, which enrolled 93 eyes with PPG of 93 patients (a mean age of 53.6 ± 1.9 years). All patients had been prescribed topical taflprost for at least 16 months and underwent at least 5 visual field examinations. Mean deviation (MD) and total deviation (TD) were measured with standard automated perimetory (Humphrey 24-2 test program), and TD slopes were calculated in the six sectors, which were previously defined by the Garway-Heath map. Sector 1 corresponds to the temporal region of the optic nerve head, sector 2 superotemporal region, sector 3 superonasal region, sector 4 nasal region, sector 5 inferonasal region, and sector 6 inferotemporal region.
There was no significant progression on total MD (P=0.193) and the total MD slope (dB/year) was -0.12±0.91 during follow up periods. There also was no progression on TD in sector 1, 2, 3, 4, and 6 (P＝0.017, P=0.995, P=0.76, P=0.352, and P=0.080, respectively) and the TD slopes (dB/year) in each sector were -0.25±0.99, 0.00±0.98, -0.04±1.15, -0.11±1.15, and -0.18±0.99, respectively. However, There was a significant progression on TD in sector 5 (P=0.001) and the TD slope was -0.38±1.43.
We found that there is region difference on deterioration speed depend on visual field loss in PPG under administration of topical taflprost. TD slope analysis in the six sectors may be clinically efficient to detect progression in eyes with PPG.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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