Abstract
Purpose :
To assess cut-point values of the integrated visual field (IVF), and their relative risk, associated with a higher risk for quality of life (QoL) loss
Methods :
Four hundred and eighty nine subjects were included in the study. Fifty one were healthy subjects and four hundred and thirty eight were glaucoma patients with different degrees of glaucoma. IVF was calculated from the monocular visual field using best location method. IVF score (IVFS) was calculated as described by Crabb. IVF was divided into six zones: ten central-upper degrees, ten central-lower degrees, external twenty degrees higher and lower and upper and lower hemifields. All subjects completed three different questionnaires. Global quality of life was evaluated with EuroQol-5D (EQ-5D). Vision related quality of life was assessed with Visual Function Questionnaire (VFQ-25) and with ocular surface disease Index (OSDI). ROC curves were built and cut-point for best sensitivity and specificity values were calculated. Relative risk for suffering bad QoL was also assessed for each dimension with a ROC area > 0.6
Results :
IVFS ≥ 3 was associated with a worse QoL related to general vision with a relative risk (RR) of 3.19. IVFS ≥ 5.5 was associated with a worse QoL related to color vision and mental health with a RR of 2.79 and 1.91, respectively. IVFS ≥ 6.5 was related to worse QoL related to dependency with a RR of 2.40. IVFS ≥ 9.5 was associated with a worse QoL related to ocular surface disease with a RR of 2.86. IVFS ≥ 10.5, 12.4 and 14.5 were associated with a worse QoL related to general vision, distance activities and peripheral vision, respectively, with a RR of 3.19, 3.30 and 2.86, respectively. All these RR had p <0.05. IVF was divided into six zones, and OSDI and the same dimensions of VFQ-25 presented the ROC areas > 0.6. Risk for loss in QoL was related to a mininum decrease in IVF in central zones and required greater loss in the peripheral zones
Conclusions :
Higher values of IVFS and small deficits in central IVF are associated to two or three folds risk of having loss of QoL in glaucoma patients
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.