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Nicola Cardascia, Alberto Maviglio, Dario Sisto, Paolo Ferreri, Giovanni Alessio; Repeated-Patteren Electroretinography, a new procedure for electrophysiological diagnosis of glaucoma that may improve Patteren Electroretinography specificity. Invest. Ophthalmol. Vis. Sci. 2016;57(12):3945.
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© ARVO (1962-2015); The Authors (2016-present)
A significant variability of the 2nd Harmonic Phase of Pattern Electroretinogram (PERGss) in intrasession repeated test has been recently described in glaucoma patients, such variability has not been found in healthy subjects. To evaluate reliability of phase variability in repeated procedure (Re-PERG) in presence of cataract, which is known to affect standard PERG, we tested this procedure in glaucomatous patients (GP), normal controls (NC) and cataract patients (CP).
The procedure was performed on 50 GP, 35 NC and 27 CP. All subjects were examined with Re-PERG and PER-GLA (PERG optimized for glaucoma), and also with SD Optical Coherence Tomography (SDOCT) and Standard Automated Perimetry (SAP). Standard deviation of phase (SDph) and amplitude value (Amp) of 2ndH were correlated, by means of one way ANOVA and Pearson correlation, with mean deviation (MD) and pattern standard deviation (PSD) assessed by SAP and SDOCT Retinal Nerve Fiber Layer (SDOCT RNFL) and Ganglion Cell Complex (SDOCT GCC) assessed by SD-OCT. Receiver operating characteristics (ROCs) were calculated in cohort populations with and whitout cataract.
SDph of 2nd Harmonic Phase was significantly higher in GP with respect to NC (p < 0.001) and CP (p < 0.001) and it was correlated with SDOCT RNFL (r=0.5, p<0.001) and SDOCT GCC (r=0.59, p<0.001) defects in GP. ROCs evaluation showed higher specificity of Re-PERG (88.85%, area under the curve 0.88) with respect to PERGLA (57.21%: area under the curve 0.72) in CP.
RePERG may improve specificity of PERGss in clinical practice in the discrimination of glaucoma patients.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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