September 2016
Volume 57, Issue 12
ARVO Annual Meeting Abstract  |   September 2016
Clinical results of Ocriplasmin versus C3F8 gas for symptomatic Vitreomacular Traction Syndrome
Author Affiliations & Notes
  • Katherine Atkins
    Ophthalmology , Royal Surrey County Hospital , Guildford, United Kingdom
  • Simon Taylor
    Ophthalmology , Royal Surrey County Hospital , Guildford, United Kingdom
  • Footnotes
    Commercial Relationships   Katherine Atkins, None; Simon Taylor, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4049. doi:
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      Katherine Atkins, Simon Taylor; Clinical results of Ocriplasmin versus C3F8 gas for symptomatic Vitreomacular Traction Syndrome. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4049.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Until recently, vitrectomy surgery was the preferred treatment for vitreomacular traction (VMT), but due to its potential complications, it is normally only performed once there is clinically significant loss of vision. It can also be costly and invasive for patients. As an alternative, intravitreal therapy can be used – ocriplasmin (Jetrea®) has recently been licenced for use in VMT and small macular holes, but is costly, and intravitreal gas injection can also be used. The purpose of this retrospective comparative case review is to evaluate the resolution rate of VMT after receiving either ocriplasmin or Perfluoropropane (C3F8 gas).

Methods : This review retrospectively analysed 20 medical records from patients with diagnosed VMT using spectral-domain optical coherence tomography (sdOCT) that underwent intravitreal injections of either Jetrea (n=10) or C3F8 gas (n=10). All treatments were administered by the same surgeon. Patients either received 0.125 mg of Jetrea as per the package guidelines or an injection of 0.3 mL of C3F8 gas. The primary outcome measure was release of VMT on sdOCT at one month after treatment. Secondary outcomes included central subfield thickness after treatment, change in visual acuity and any side effects/complications.

Results : 50% had resolution of vitreomacular traction on sdOCT by one month after Jetrea injection compared to 80% of patients treated with C3F8 gas. Mean visual acuity at one month improved by a mean of +10.3 letters following ocriplasmin compared to only +0.4 letters after C3F8 gas, probably representing persistence of the gas bubble. Consistent with this, central subfield thickness on sdOCT decreased by an average of 39 microns after injection in patients that received gas compared to only 4.9 microns in the group of patients that received ocriplasmin. No patients developed retinal tears or detachment.

Conclusions : C3F8 gas proved to be of similar effectiveness to Ocriplasmin in our small study, providing effective release of VMT. This study suggests that C3F8 gas could provide a cost effective and readily available alternative treatment for patients and that a larger prospective trial would be worthwhile to establish its use in the standard treatment pathway for VMT.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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