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Lindsay Grotting, Samaneh Davoudi, George Papaliodis, Lucia Sobrin; Association of Vitamin D Levels with Non-infectious Uveitis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4137.
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Vitamin D has been shown to play an important role in both the innate and adaptive immune system and contribute to the etiology of T-cell mediated autoimmune diseases through up regulation of anti-inflammatory T helper cells type 2 and the suppression of T helper cells type 1. Given that non-infectious uveitis is postulated to be caused by immune dysfunction, the purpose of this study was to determine if there is an association between Vitamin D levels and the development non-infectious uveitis.
In this retrospective study, we identified patients with and without non-infectious uveitis using the Massachusetts Eye and Ear Infirmary electronic medical record and Uveitis Database. Non-infectious uveitis patients were diagnosed by fellowship-trained uveitis specialists after exclusion of infectious and neoplastic causes of uveitis. Controls were primarily patients seen for refractive error or cataracts without any history of uveitis. All patients included had a total 25 (OH) Vitamin D level measured by mass spectroscopy in our centralized laboratory. Clinical and demographic information including anatomical location of uveitis, associated systemic autoimmune disease, age, gender, race and history of vitamin D supplements were recorded from patients’ medical records. Multivariate regression models were created with Stata (College Station, Texas) to determine the association between Vitamin D levels and the presence of uveitis.
We identified 53 non-infectious uveitis patients with the mean age of 53 years (75.4% female) and 50 controls without uveitis with the mean age of 66.5 years (74% female). Uveitis patients had lower mean vitamin D levels: 26.2 nanograms per milliliter in cases vs. 35.7 nanograms per milliliter in controls. The odds of developing uveitis were 6% lower for every 1 unit increase in Vitamin D level [odds ratio = 0.94, 95% confidence interval (CI) 0.91-0.98, P = 0.001] in the univariate analysis. This association persisted in a multivariate regression model (OR = 0.95, 95% CI 0.92-0.99, P = 0.012) with adjustment for age, gender, race and history of taking vitamin D supplements.
Lower vitamin D levels were associated with increased risk of non-infectious uveitis in this retrospective study. Expansion of this study is underway to further corroborate this initial finding.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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