September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Author Affiliations & Notes
  • Paola Carrai
    University of Milan, Milan, Italy
  • Francesco Pichi
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    San Giuseppe Hospital, Milan, Italy
  • Alessandro Invernizzi
    Ospedale Sacco, Milan, Italy
  • Alessandro Mantovani
    Ospedale Valduce, Como, Italy
  • Federico Ricci
    Tor Vergata, Roma, Italy
  • Giovanni Staurenghi
    Ospedale Sacco, Milan, Italy
  • Sunil K Srivastava
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Paola Carrai, None; Francesco Pichi, None; Alessandro Invernizzi, None; Alessandro Mantovani, None; Federico Ricci, None; Giovanni Staurenghi, None; Sunil Srivastava, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4138. doi:
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      Paola Carrai, Francesco Pichi, Alessandro Invernizzi, Alessandro Mantovani, Federico Ricci, Giovanni Staurenghi, Sunil K Srivastava; MULTIMODAL IMAGING OF KYRIELEIS PLAQUES. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4138. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Kyrieleis’ retinal periarteritis reflects the severe intraocular inflammation experienced by the eye. Its etiology has not been well established, since only 9 cases have been reported and there is no pathological study available in the literature. We determine the pathogenesis of Kyrieleis’ periarteritis based on interpretation of multimodal imaging findings.

Methods : Charts of patients with Kyrieleis arteritis seen between 2006 and 2014 were retrieved from 8 Uveitis referral center throughout the world. Follow-up ranged from 5 to 12 months.

Results : Twenty-five eyes with Kyrieleis arteritis from 25 patients were included in the study. Nineteen patients (72%) were male and six (28%) were female. Twenty-three patients were diagnosed with toxoplasmosis retinochoroiditis and 2 patients had cytomegalovirus retinitis. Fluorescein angiography, fundus autofluorescence and indocyanine green angiography were performed on 25/25 (100%) eyes. In 8 eyes (32%), baseline SD-OCT scans were performed along the segmental Kyrieleis arteritis. Fluorescein angiography showed early hypofluorescence and intermediate hyperfluorescence associated with the areas of focal arteritis, whereas indocyanine green angiography of these accumulations showed early hypofluorescence and late hyperfluorescence. Fundus autofluorescence revealed an increased autofluorescence of the vessels corresponding to the Kyrieleis plaques, while SD-OCT scans along the segmental Kyrieleis arteritis showed an hyperreflectivity of the vessel wall.

Conclusions : These imaging modalities provide in vivo, quasi-histologic images demonstrating that Kyrieleis plaques are not a periarteritis, but are characterized by an inflammatory involvement limited to the vessels’ endothelium.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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