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Rosalva Bobadilla, Miguel Pedroza-Seres; Vogt Koyanagi Harada Syndrome a review of 114 patients in Mexican population. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4146. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To describe demographic data, treatment and complications of patients with diagnosis of Vogt Koyanagi Harada Syndrome seen in the department of uveitis and ocular immunology in an ophthalmologic reference Centre in Mexico
We analyzed all the electronic records from January 2002 to March 2015, selecting those diagnosed with Vogt Koyanagi Harada Syndrome. We include demographic data, symptoms at the onset of the diseases, clinical complications and treatment.
we found 114 patients with this diagnosis in a period of 13 years. Eighty five were female (74%) and 29 (25.43%) male, with an average of 36.17 years at the beginning of the symptoms. With a mean follow-up of 34 months. Sixty eight (59.64%) patients were diagnosed in our Centre and 46(40.35%) had previous diagnosis. Visual acuity was registered at all visits and were classified in five groups being excellent (-0.1249 – 0.0969 LogMar), good (0.1760 – 0.4771 LogMar), regular (0.5440 – 1.3010 LogMar), bad (1.6020 – 2.3010 LogMar) or non-functional (CF-NLP), treatment included topical, oral or intravenous steroids or even immunosupression depending on the severity of the clinical signs and the delayed diagnosis. The clinical manifestations of the patients diagnosed in Centre were: serous retinal detachment in 49, optic disc hyperemia in 38 patients and papilitis in 15. We classified this syndrome according the clinical manifestations in: probable 55 patients (48.24), incomplete in 63 patients (55.26%) and only one complete (0.87%). Initial IOP average was 13.0mmHg, and 13.8mmHg at the final visit. At the follow-up we observe 47 patients (41.22%) with at least one recurrence. The more frequent complications were: cataract in 25 patients (21.9%), ocular hypertension in 20 patients (17.7%) and epiretinal membrane in 9 patients (7.8%). We observe at the last visit the late clinical characteristics of the disease and included: pigmented dispersion in posterior pole and mid-periphery in 81 patients (71.05%), sunset glow fundus in 55 patients (48.24%), numular scars in 55 patients (48.24%) and vitiligo in 38 patients (33.3%).
Vogt Koyanagi Harada syndrome is frequently seen in oriental and Hispanic population although the pathology is well described, exists differences in clinical findings at the onset and relapses. We found differences in regimen treatment and improvement
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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