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Rayan Alshareef, Vincent Sun, Andrei Dan, Michael Kapusta; Optical Density of Subretinal Fluid in Proliferative Vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4260.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the optical density ratio in rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopathy (PVR) obtained from subretinal fluid (SRF) analyses to identify the diagnostic role clinical relevance in comparison to age matched patients with RRD and no clinical evidence of PVR.
Patients with first-onset RRD with or without proliferative retinopathy (Grade B or C) and no history of intraocular illness or intraocular sugrery who underwent optical coherence tomography (OCT) and whose OCT scans showed sufficient SRF for sampling. The highest quality B-scan (as graded by the OCT image acquisition software) containing SRF was analyzed. Images were generated using horizontal scans within subretinal fluid areas. Raw scan data were exported and used to calculate light reflectivity profiles using image J software. Reflectivity data were acquired by projecting two identical rectangular boxes onto the subretinal spaces and the corresponding vitreous. Light reflectivity in the vitreous and subretinal spaces for the various pathologies were measured. ODRs were calculated by dividing the mean pixel intensity of the SRF by the mean pixel intensity of the vitreous. Patients were divided into two groups: first-onset RRD with PVR and first-onset RRD without PVR. In addition, the optical density ratios were calculated from the SRF to the retinal pigment epithelium (RPE), and retinal nerve fiber layer (RNFL) reflectivity ratios
Fourty-two eyes (42 patients) met the inclusion criteria. The ODR measurement was significantly higher in patients with PVR than those with RRD. Optical density ratios of SRF to the RPE and RNFL were higher but not statistically significant in patients with PVR than in those without PVR.
The optical density ratio differs significantly between RRD with PVR and RRD without PVR. This suggests the usefulness of this parameter in differentiating between RRD with or withour PVR.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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