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Yasushi Ikuno; Polarization sensitive OCT: Clinical application. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
Fibrous tissues are distributed widely inside the eyeball, and tissues such as nerve fiber layers, lamina cribrosa, and sclera are prime targets for development of major ocular pathologies including pathological myopia, glaucoma, uveitis, and choroidal neovascularization. Fibrous tissues are critical not only for maintaining homeostasis but also playing a major role in challenging retinal diseases (i.e., inflammation and neovascularization). It is critical to identify the tissue location and characteristics to understand the pathogenesis in vivo. To locate fibrous tissues and identify their properties, local measurement of birefringence is an ideal method. We recently developed a bayesian estimator for birefringence imaging for precise quantification in tissue. In addition, multifunctional Jones matrix optical coherence tomography (MF-OCT) has been developed that provides scattering, phase retardation, degree-of-polarization uniformity (DOPU), and Doppler imaging simultaneously. This technology facilitates acquisition of additional information such as vasculature and fibrous tissue properties to investigate pathology in ocular tissues. We will provide an overview of a case series of posterior diseases examined using MF-OCT. The cases demonstrate the scattering (regular) in an OCT image, blood flow, and fibrous tissues at an identical image, which provides more detailed information and a profile of the posterior ocular tissues. This technology also visualizes the deep ocular tissues such as the sclera and lamina cribrosa, which should be helpful in determining the underlying mechanism of myopia and glaucoma.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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