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Maximilian Kurz, Annekatrin Holzhey, Salvatore Grisanti, Mahdy Ranjbar; Clinical evaluation of stereotactic low-voltage X-ray irradiation for neovascular age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4425. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the clinical and morphological outcome of stereotactic low voltage X-ray irradiation (SRT) in patients with neovascular age-related macular degeneration (nAMD) under real-life circumstances.
37patients, selected by the criteria for best responders as determined by the INTREPID study, were treated with 16 Gray SRT. All patients received pro re nata (PRN) aflibercept, bevacizumab or ranibizumab. Evaluation based on visual acuity, morphological changes as described by OCT, multifocal-ERG and number of applied injections.
Patients showed a significant increase of visual acuity, morphological improvement of retinal integrity, despite significantly less injections. No electrophysiological adverse effects of SRT were recorded during the first year after treatment.
Our results might indicate that a single dose of low-voltage x-ray irradiation in patients with age-related macular degeneration significantly reduces intravitreal injections over 12 months. This is not only relevant for the patients from a quality of life perspective, but also due to the demographic trend of our society from an economical point of view.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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