Abstract
Purpose :
To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy (PVR) after open globe trauma in smokers and non-smokers.
Methods :
A retrospective review of 892 patients comprising 893 open globe injuries presenting to the Massachusetts Eye and Ear Infirmary (MEEI) between 1999 and 2011 was undertaken. Retinal detachment (RD) was diagnosed in 255 eyes and 138 underwent successful surgical repair. Time to redetachment was calculated using the Kaplan-Meier method and risk factors were determined using Cox proportional hazards modeling.
Results :
Within one year after retinal detachment surgery, 47% (95% CI, 39%-56%) of all 138 repaired retinas redetached due to PVR. Being a smoker was associated with a higher rate of failure (adjusted Hazard Ratio (HR) 1.96 p=0.01). As shown in prior studies, the presence of PVR at the time of surgery was also an independent risk factor for failure (adjusted HR 2.13, p=0.005). Treatment with vitrectomy-buckle compared favorably to vitrectomy alone (adjusted HR 0.58, p=0.04). Only 8% of eyes that redetached achieved a best corrected visual acuity of 20/200 or better, in comparison to 44% of eyes that did not redetach (p<0.001).
Conclusions :
Proliferative vitreoretinopathy is a common complication after the repair of retinal detachment associated with open globe trauma, and being a smoker is a risk factor for redetachment. Further study is needed to understand the pathophysiologic mechanisms underlying this correlation.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.