Optical Coherence Tomography Angiography Features of Polypoidal Choroidal Vasculopathy and its Correlation with Indocyanine Green Angiography

Abstract

Purpose : Polypoidal choroidal vasculopathy (PCV) occurs more commonly in Asian populations and is currently diagnosed via indocyanine green angiography (ICGA). Though the ICGA features of PCV have been described, there is little information on its characteristics seen on optical coherence tomography angiography (OCTA). We aimed to describe the OCTA features of PCV as well as correlate these features with ICGA.

Methods : A study of 24 eyes of 24 consecutive patients with PCV seen at Tan Tock Seng Hospital, Singapore. The diagnosis of PCV was confirmed using standardized diagnostic criteria. The OCTA images of these patients were then described and then correlated with the ICGA images

Results : The mean age of the 24 patients was 68.5 years. Of these, 87.5% were male and 12.5 % females. The most common OCTA feature was branching vascular network (BVN) at the choriocapillaris which occurred in 95 % of eyes. BVN was also seen in 70% of patients at the outer retina but not in the superficial or deep retina. Other features of PCV include polyps, which were most commonly seen in the choriocapillaris (78.6%) and outer retina (71.4%). The most common polyp feature over these layers was a internal architecture and hollow structure respectively. Correlating with ICGA findings, 54.2% of BVN were more easily seen on OCTA then ICGA compared to 13.3% for polyps

Conclusions : We have described novel and distinct OCTA features of PCV that correlates well with the features seen on ICGA. OCTA provides a non-invasive means to image and diagnose patients and may aid in the diagnosis of PCV in patients who are allergic to ICG in the future.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.