September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016

Drug Release Profiles from Ophthalmic Ointment Formulations
Author Affiliations & Notes
  • Roy Bryant
    Stability and Analytical Services, Encompass Pharmaceutucal Services, Peachtree Corners, Georgia, United States
  • Footnotes
    Commercial Relationships   Roy Bryant, Encompass Pharmaceutical Services (E)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5038. doi:
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    • Get Citation

      Roy Bryant;
      Drug Release Profiles from Ophthalmic Ointment Formulations
      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):5038.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Drug release profiled have been a common element in the characterization of systemic drugs for decades. A similar quality attribute needed to be controlled in ophthalmology as well. A model for release of drug from viscous ophthalmic formulations is presented.

Methods : A dynamic diffusion model was used to simulate ocular conditions. Various formulations were tested using both synthetic and animal membranes. Samples were collected to compare the effect of formulations on the drug release profile.

Results : Results: There were significant differences in the diffusion characteristics when comparing the diffusion profile of various ointment formulations. Synthetic membranes showed promise as a substitute for using ex-vivo tissue.

Conclusions : It is possible to use an in-vitro model as a quality release test for the ophthalmic drug release profile.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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