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Sushant Wagley, Gina Yu, Gianna C Teague, Kameran Lashkari, Jorge G Arroyo; Vitreous cytokine profile immediately following phacoemulsification with posterior chamber intraocular lens placement. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5043.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify the immediate intraoperative effects of phacoemulsification with posterior chamber intraocular lens implantation (PE/PCIOL) on vitreous cytokines levels.
Vitreous samples collected during surgery were retrospectively analyzed in three groups: 1) patients that received PE/PCIOL immediately followed by pars plana vitrectomy (PPV), 2) patients that had previously received PE/PCIOL (pseudophakic) who underwent PPV at a later date, 3) those who never had PE/PCIOL (phakic) but only received PPV. Vitreous inflammatory cytokine markers were quantified and compared (using T-test) between these groups
There was no significant difference in vitreous inflammatory cytokine levels between patients that received combined PE/PCIOL with PPV (Group 1) vs. phakic patients that only received PPV (Group 3). Patients who were pseudophakic and later received PPV (Group 2) had elevated inflammatory cytokines compared to those that received combined PE/PCIOL with PPV (Group 1) and had significantly elevated levels compared to phakic patients that only received PPV (Groups 3). There was significant elevations in Angiopoetin 2, PAI-1, IL-8, and TGF-alpha in Group 2 compared to Group 3 as well as significant elevations in Angiopoetin 2, PAI-1, sFASL, and PECAM-1 in Group 2 compared to Group 1.
While there is an eventual rise in vitreous cytokines, there is no significant immediate elevation of inflammatory cytokines following PE/PCIOL. Precise timing and quantification of inflammatory cytokines needs further analysis to understand intraocular inflammatory response following PE/PCIOL.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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