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Ari Kamei, Eiichiro Nagasaka; Central Multifocal Photopic Negative Response (mfPhNR) and Ganglion Cell-Inner Plexiform Layer Thickness (GCIPLT) in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5076.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the interrelation of mfPhNR and GCIPLT in nasal and temporal in patients with optic nerve lesions.
Twelve eyes of twelve volunteers with normal vision and eighteen eyes of nine patients with optic nerve lesions including normal tension glaucoma (NTG) were tested.The mfPhNR was recorded with the VERIS Science System 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, Pseudo-randomly alternating between black (5cd/m2) and white (200cd/m2) on the CRT monitor. Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. The recording time was approximately 8 min. with dilated pupils having the best-corrected visual acuity. The band pass filter of the amplifier was set from 1 to 100 Hz. The amplification and stimulus frequency were set to 10000 and 9.41 Hz (8 frames) respectively.Each trace of the mfPhNR found in nasal and temporal regions was analyzed in about 10 degrees.The GCIPLT was measured using the Cirrus HD-OCT. The GCIPLT in nasal and temporal was applied for analysis.
There was a correlation between the amplitude of the temporal mfPhNR and the temporal GCIPLT (R=0.497887, P=0.007336). On the other hand, there was no correlation between the amplitude of the nasal mfPhNR and the nasal GCIPLT (R=0.186318, P=0.321381).
There was the different correlation between the amplitude of the temporal mfPhNR and the temporal GCIPLT and the amplitude of the nasal mfPhNR and the nasal GCIPLT in central retina.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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