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Jan D Unterlauft, Peter MH Wiedemann; Laser Peripheral Iridotomy changes Anterior Chamber Architecture significantly in Acute Angle Closure. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5134.
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© ARVO (1962-2015); The Authors (2016-present)
The pressure gradient between anterior and posterior chamber in acute angle closure (AAC) and primary angle closure suspects (PACS) can be balanced by a sufficient laser peripheral iridotomy (LPI). The changes induced by LPI in patients suffering from unilateral AAC were examined using Scheimpflug-photography techniques and were compared to healthy eyes to define threshold values which may help to discriminate between healthy and diseased eyes.
Using Scheimpflug photography anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) and central corneal thickness (CCT) were measured before and after LPI in both eyes of unilateral AAC cases. These measurements were compared to a group of healthy control eyes using receiver operating characteristic (ROC) analysis to determine threshold values for ACD, ACV and ACA.
ACD, ACV and ACA increased significantly after LPI in the 25 eyes suffering from unilateral AAC. ACD, ACV, ACA and CCT values in the AAC eyes obtained before LPI were compared to a control group of 59 healthy eyes with wide open chamber angles. The cut-off values revealed by ROC analysis were 2.1 mm for ACD, 90.5mm2 for ACV and 27.25° for ACA.
The results confirm the significant changes of anterior segment architecture induced by LPI in AAC eyes. The found threshold values for ACD, ACV and ACA may help in daily clinical routine to discriminate between healthy eyes and those in need for a prophylactic LPI.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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