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Young Jung Roh, Ralf Brinkmann, Young Gun Park; The 12-months Results of Selective Retina Therapy (SRT) for the Treatment of Diabetic Macular Edema in Korean Patients.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5356.
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© ARVO (1962-2015); The Authors (2016-present)
Selective retina therapy (SRT) selectively targets the RPE and spares the neurosensory retina without causing microscotoma. This is a prospective, nonrandomized interventional case series study to investigate the safety and efficacy of Selective retina therapy(SRT) in Korean patients with diabetic macular edema for 12-months follow-up.
Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 12 months. Thirteen eyes (57%) had completed follow-up. Patients underwent a best-corrected visual acuity (BCVA) evaluation in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure the macular sensitivity within the central 10° field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured. Retreatment and rescue therapy was performed based on study protocol. Data were analyzed by the paired t-test.
The mean ETDRS letters increased from 69.5 ± 11.9 to 71.3 ± 9.8 at 12-months. Although the CMT was not significantly reduced from 331.1 ± 98.92 to 303.01 ± 66.47 μm , the MMT significantly decreased from 446.77 ± 78.49 μm to 408.5 ± 59.62 μm (P=0.025). The macular sensitivity increased from 21.5 ± 3.4db to 22.5 ± 3.5db (P=0.001). Additional SRT was performed for nine eyes (69.2%) and rescue treatment with anti-VEGF agents were needed for five patients (38.5%).
SRT proved to be efficacious and safe for the treatment of diabetic macular edema throughout the 12-month follow up. To evaluate its long-term efficacy, further studies are required with larger numbers of patients and longer observational follow-up periods.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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