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Mohamed Saleh, Liang Liu, Yali Jia, David Huang, James T Rosenbaum, Eric B Suhler, Phoebe Lin; Macular retinal vascular flow characteristics in birdshot chorioretinopathy using optical coherence tomography angiography .. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5471.
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© ARVO (1962-2015); The Authors (2016-present)
Birdshot chorioretinopathy (BSCR) is characterized by classic deep choroidal lesions, occasional retinal vascular or optic nerve leakage, and eventual choroidal and outer retinal atrophy. The purpose of this study was to quantify retinal vascular changes in the macular area in patients with BSCR using optical coherence tomography angiography (OCTA).
This was a prospective case series of 11 eyes of 6 patients with BSCR and 8 eyes from 8 normal age-similar subjects imaged with a 3x3 mm scan by a high-speed (70 kHz) 840 nm spectrometer-based OCT system SD-OCT (Optovue RTVue XR Avanti). The split-spectrum amplitude decorrelation angiography (SSADA) algorithm was used to compute angiograms from the internal limiting membrane to the outer plexiform layer. The parafoveal retinal flow index and vessel density were determined in a 2.5 mm wide annulus centered on the fovea. The retinal vessel density was defined as the percentage area occupied by vessels on the en face angiogram. The flow index is a measure that includes the SSADA-derived flow velocity in capillaries and the area of large vessels on the en face angiogram. A Mann–Whitney U test was used to compare these flow characteristics between BSCR patients and normal subjects.
Mean age of BSCR subjects was 60.8 years (range 34-70) compared to mean age of 60.3 years in normal subjects (range 32-72) (p=1.0). All BSCR subjects were positive for HLA-A29. The parafoveal retinal vessel density via OCTA was significantly lower in BSCR patients compared to normal subjects (mean parafoveal vessel density 80.2% vs. 91.7%, p=0.003). The parafoveal retinal flow index was also significantly lower in BSCR subjects compared to normal subjects (mean flow index 0.06 vs. 0.08, p<0.0001).
Retinal blood flow in the parafoveal area of patients with BSCR is reduced compared to age-similar subjects suggesting possible disruption of the blood retinal barrier.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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