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Itaru Kimura, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Takuhei Shoji, Makoto Araie, Shin Yoneya; Foveal avascular zone measurements by high resolution femtosecond mode-locked laser optical coherence tomogramphy in healthy eyes. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5499.
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© ARVO (1962-2015); The Authors (2016-present)
Foveal avascular zone (FAZ) area has been measured by means of femtosecond mode-locked laser optical coherence tomography (OCT) that we developed. We measured FAZ area using en-face images obtained by this OCT in healthy eyes.
In right eyes of 10 healthy subjects (8 males and 2 females with an average age of 35.6±7.8 y/o), a total of 300 macular single B-scans (3 mm x 3 mm) centered on the foveola were obtained in 10-μm steps using high resolution mode-locked laser OCT installing an ultra-broadband Kerr lens mode-locked Ti:Sapphire laser and a wideband spectrometer. The spectral bandwidth of the light source was 200 nm full-width at half maximum at a central wavelength of 840 nm. A high-speed CCD camera with 2048×300 pixels (Basler, Ahrensburg, Germany) was used as the detection system. The measurement speed was 50,000 depth-scans/s, and depth resolution was measured to be less than 2.0 μm into the tissue (Kuroda H, et al, Applied Physics Letters 2013). Three-dimensional images were rendered from these image sequences to obtain 2-μm thin slice en-face images of macular area. The nasal and temporal distances from foveola to the nearest vessels in the superficial ganglion cell layers were measured.
The FAZ areas in the superficial ganglion cell layer could be apparently observed in the en-face images thus obtained. The averaged distances from the foveola to the nearest nasal and temporal vessels were 242.0±48.9μm and 262.0±86.3μm (N=10), with no significant difference, respectively, and the mean horizontal FAZ diameter was 504.0±127.2μm. The current result was compatible with those reported using OCT angiographic technique, for example, 573±177μm in healthy eyes (Freiberg FJ, et al, Graefes Arch Clin Exp Ophthalmol 2015).
En-face images need short aquisition time and exact 3-D images can be structured in the femtosecond mode-locked laser OCT that we developed. FAZ area can be measured by means of this OCT .
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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