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David C Musch, Leslie M Niziol, Brenda W Gillespie; Binocular Measures of Visual Function versus Monocular-based Approximations. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5596.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the relationship of binocular visual function measures with monocular approximations, using data from the Collaborative Initial Glaucoma Treatment Study (CIGTS).
607 subjects with newly diagnosed open-angle glaucoma participated in the CIGTS. Visual field (VF) and visual acuity (VA) measures were taken at baseline and every 6 months thereafter. Binocular tests of visual function (Esterman VF score; binocular VA) were added to the CIGTS protocol 3 years into the study. Among the 7 monocular-based approximations of binocular visual function were better eye, worse eye, average eye, best location, and binocular summation. Associations between binocular test results and monocular approximations to represent binocular visual function were assessed with Pearson’s correlations (r), as was the relationship between quality of life [QOL, by the Visual Activities Questionnaire (VAQ) and the National Eye Institute Visual Function Questionnaire (NEI-VFQ25)] and monocular or binocular visual function.
575 subjects had at least 1 binocular visual function measure. The Esterman score was significantly correlated with all monocular approximations of binocular MD, with r-values ranging from 0.33 (worse eye MD) to 0.44 (better eye MD, all p<0.0001). Binocular VA showed larger correlations with monocular approximations, with r-values ranging from 0.65 (worse eye VA) to 0.77 (binocular summation, all p<0.0001). Correlations between the VAQ and Esterman score were largest in 7 of 9 subscales (r =-0.14 to -0.25, all p<0.05) than correlations with all 7 monocular approximations. In contrast, correlations between the VAQ and binocular VA (r=-0.07 to -0.21) were smaller in all subscales than those with better eye, average eye, and binocular summation of VA (r=-0.09 to -0.25), but not different from worse eye. These trends were also found in relevant subscales of the NEI-VFQ25.
Correlations between VA measured binocularly and monocular approximations were larger than similar comparisons between VF measured binocularly and monocular approximations. The best monocular approximation of binocular VA was binocular summation, and of binocular VF was the better eye VF. Correlations of VA and VF with the VAQ were modest. Most monocular approximations of binocular VA correlated better with the VAQ than binocular VA. In contrast, binocular VF correlated better with the VAQ than monocular approximations.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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