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Tomohito Sato, Masaru Takeuchi, Yoko Karasawa, Haruna Shimazaki, Shinpei Sugaoka, Hideaki Someya, Manzou Taguchi, Takayuki Kanda, Masataka Ito, Toshio Enoki; Correlations between intraocular pressure, duration of acute glaucoma and levels of cytokines in aqueous humor in patients with first acute glaucoma attack. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5620.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze correlations between intraocular pressure (IOP), duration of acute glaucoma and levels of cytokines in aqueous humor in patients with first acute glaucoma attack.
This retrospective case control study enrolled 9 eyes of 9 patients with first acute glaucoma attack who had undergone cataract surgery to cure the attack finally. Four eyes of 4 patients (acute glaucoma attack group with laser peripheral iridotomy (LPI); 4 females, average age±standard deviation (SD) : 72.3±9.81 years old, mean IOP before cataract surgery: 39.5±30.6 mmHg, mean duration of acute glaucoma before cataract surgery: 10.3±11.3 days) had undergone conservative treatments such as IOP-reducing drops, internal drugs and intravenous drips, and then had been treated with LPI which had not been successful, and 5 eyes of 5 patients (acute glaucoma attack group without LPI; 1 male, 4 females, the average age: 80.4±4.39 years old, the mean IOP: 36.4±20.8 mmHg, the mean duration: 19.4±21.6 days) had undergone similar conservative treatments without LPI. Twenty nine eyes of 21 patients who underwent cataract surgery were used as controls. Undiluted aqueous humor samples were collected at the initiation of cataract surgery. The levels of IL-1β, IL-8, IL-10, IL-12, G-CSF, IP-10 and VEGF in the samples were measured by a multiplex bead array. Correlations between the IOP, the duration and the levels of cytokines were analyzed using Spearman's correlation. P value under 0.05 was considered significant.
In control group and acute glaucoma attack group without LPI, there was no significant difference between the IOP and the levels of cytokines. In acute glaucoma attack group without LPI, there were negative correlations between the duration and the levels of IL-1β, IL-10, IL-12. In acute glaucoma attack group with LPI, there were positive correlations between the IOP and the levels of IL-8, IL-10, IL-12, VEGF, and there was positive correlation between the duration and the level of G-CSF, and was negative correlation between the duration and the level of IP-10.
In eyes with first acute glaucoma attack, persist high IOP after LPI could be associated with induction of vascularization and infiltration of inflammatory cells, and the lengthening of duration under persist high IOP suggested that infiltration of inflammatory cells was extenuated.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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