September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Dynamics of autophagy and mitophagy in neuronal homeostasis and neurodegeneration
Author Affiliations & Notes
  • Erika Holzbaur
    Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Erika Holzbaur, None
  • Footnotes
    Support  R37 NS060698
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Erika Holzbaur; Dynamics of autophagy and mitophagy in neuronal homeostasis and neurodegeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):No Pagination Specified.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Presentation Description : Macroautophagy is required to maintain neuronal health and function. The turnover of aggregated proteins and dysfunctional organelles is required to maintain homeostasis. Recent progress using live cell imaging has identified novel pathways for both constitutive autophagy along the axon and selective removal of damaged mitochondria via mitophagy. The underlying mechanisms and the role of these dynamics in maintaining neuronal health will be discussed.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.