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James T Handa; Age and oxidative stress in the retina. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
The redox aging theory suggests that aging is the decline in the adaptive interface of the functional genome and the exposome that occurs due to cell and tissue differentiation, and cumulative injury resulting from an impaired response to oxidative stress. The high oxidative stress environment of the retina combined with the declining antioxidant response makes it vulnerable to oxidative damage. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that is induced by oxidative stress. The wingless (WNT) signaling pathway is a vast network of well-conserved lipid modified glycoproteins that influence changes in gene expression to govern cellular differentiation and survival, and its dysregulation has been implicated in aging, degenerative diseases, and carcinogenesis. WNT also has antioxidant capability as part of its role in survival. This talk will focus on the Nrf2 and WNT signaling systems and how their decline can be associated with retinal pigment epithelial cell dysfunction and death during aging and age-related macular degeneration.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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