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Daisuke Inoue, Masafumi Uematsu, Ryotaro Ueki, Naoki Imamura, Yasser Helmy Mohamed, Azusa Fujikawa, Takashi Kitaoka; Acute corneal toxicity of conjunctival disinfectants.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5725.
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© ARVO (1962-2015); The Authors (2016-present)
It is very important to avoid endophthlmitis after intraocular surgery by disinfectant, but several disinfectants may sometimes be harmful for ocular surface. The purpose of this study is to investigate the corneal toxicity of three conjunctival disinfectants using transepithelial electrical resistance [TER].
Corneal TER changes after a 60-second exposure to 0.25% povidone-iodine [PI], 4-fold diluted polyvinyl alcohol-iodine [PAI], and 0.02% chlorhexidine gluconate [CG] were measured in living rabbits. Hank’s balanced salt solution was used as a control.
The corneal TER after a 60-second exposure to CG decreased to 14.1 +/- 3.7%. This result was statiscally significant compared to other two disinfectants and control (p<0.05). No statistically significant differences were found among other groups.
We concluded that the corneal toxicity of chlorhexidine gluconate is higher than other two disinfectants.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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