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Jonathan Benesty, Edouard Koch, David Rosenbaum, Xavier Girerd, Jose Sahel, Caroline Kulcsar, Guy Le Besnerais, Michel Paques; High resolution imaging of retinal vascular deformations in synchrony with the cardiac cycle. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5912.
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© ARVO (1962-2015); The Authors (2016-present)
Retinal vessels show dynamic deformations in synchrony with the cardiac cycle, resulting from the interaction of the systolic pulse and of intraocular pressure variations, but also possibly in relation with arterial geometry and arteriovenous interactions. Modeling these different factors may help to uncover arterial compliance, a major determinant of cardiovascular and cerebral health. Here, we analyzed the cyclic changes in vascular geometry in relation with the cardiac cycle using flood-illuminated adaptive optics (FIAO) imaging
FIAO image stacks (rtx1 camera, ImagineEye, France; 40 images in 4 seconds; field of view 1.2° x 1.2°) of retinal arteries were acquired in healthy subjects. The evaluation of the movement of the axial reflection and movement of the wall to the axial reflection was measured using custom software under subpixellic registration using affine registration and optical flow (Matlab, Mathworks, Natick, Massachusetts, USA).Relationships between arterial and venous motions were also investigated.
10 arterial and venous segments were analyzed. The software allowed quantifying the intensity of arterial deformation (longitudinal and transverse). The diameter increase was 1 to 2 pixels (0.8 to 1.6µm). The increase of tortuosity with systolic pulse was correlated with the local radius of curvature. In one case, movements of the adjacent vein were parallel to the arterial.
Retinal vessels variations results from multiple factors. FIAO imaging may be helpful to progress in the modeling of the biomechanical factors involved in dynamic deformation of vessels in synchrony with the cardiac cycle. Arteriovenous interactions suggest that arterial variation modulates venous flow. We postulate that the respective imbalance of transverse (i.e. enlargment of arterial diameter) and longitudinal pulse (i.e. elongation) may influence long-term remodelling of arterial geometry but also influence venous outflow.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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