September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Altered T cell immunity in patients with Posner-Schlossmann syndrome
Author Affiliations & Notes
  • Jin A Choi
    Ophthalmology, St. Vincent's Hospital, Suwon, Gyunggi-do, Korea (the Republic of)
  • Seung-June Noh
    Ophthalmology, St. Vincent's Hospital, Suwon, Gyunggi-do, Korea (the Republic of)
  • Soon-Young Paik
    Microbiology, Catholic university of Korea, Seoul, Korea (the Republic of)
  • Chankee Park
    Ophthalmology, Seoul St.Mary's Hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Jin A Choi, None; Seung-June Noh, None; Soon-Young Paik, None; Chankee Park, None
  • Footnotes
    Support  This research was supported by the Catholic Medical Center Research Foundation made in the program year of 2014 (5-2014-B001-00184) and the St.Vincent’s hospital, research institute of medical science (SVHR-2013-14).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5999. doi:
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      Jin A Choi, Seung-June Noh, Soon-Young Paik, Chankee Park; Altered T cell immunity in patients with Posner-Schlossmann syndrome. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5999. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Posner-Schlossmann syndrome(PSS) is characterized by recurrent attacks of mild anterior uveitis associated with marked elevations of intraocular pressure(IOP). Our goal was to explore changes in T cell immunity in patients with PSS.

Methods : Peripheral blood samples were obtained at the hypertensive phase with aqueous inflammation in study patients(n=15), and during cataract surgery in controls(n=11). All patients underwent a serological screening for IgGs against herpes simplex virus and cytomegalovirus. The counts of each T-cell subpopulation were determined via flow cytometry. The concentrations of inflammatory cytokines were measured using Luminex multiplex bead immunoassay.

Results : The baseline IOP of the PSS group was significantly higher than that of the control group(P<0.001) and the corneal endothelial cell count in the PSS group was significantly lower than that of the control group(P<0.001). The PSS group had a significantly lower absolute lymphocyte count (1,931±325 cells/mm2) than the control group (2,328±507 cells/mm2; P=0.041) and reduced numbers of CD4+ and CD8+ T cells (P=0.058 and 0.029, respectively). In the same group, the CD8+CD28- and CD8+CD57+ T cell numbers, indicating the T cell immunosenescence were marginally lower than in the control group (P=0.085 and 0.085, respectively). Serum IL-2, TGFβ1, and TGFβ2 levels were lower in the PSS than the control group (P=0.056, 0.012, and 0.062, respectively).

Conclusions : PSS patients do not appear to exhibit typical immune aging. Rather, PSS seems to be associated with systemic immune activation and relative lymphopenia. This is the first description of altered T cell immunity in PSS patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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