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Vincent Nguyen, Prabjot Channa; The Association of Fuchs’ Corneal Endothelial Dystrophy and Narrow Angles in the Bronx Population. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6216.
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In our Bronx population we started to notice shallow anterior chambers in our Fuchs’ Corneal Endothelial Dystrophy patients. Upon review there are limited studies that have found an assocation with Fuchs’ Corneal Endothelial Dystrophy with other ocular conditions such as glaucoma, and none in our particular population. We decided to investigate whether Fuchs’ Corneal Endothelial Dystrophy (FCED) is associated with anatomic narrow angles or closed angle glaucoma in our subset of the Bronx population in a retrospective, observational chart review.
This is a retrospective observational chart review study measuring associations of Fuchs’ Corneal Endothelial Dystrophy (FCED) and anatomic narrow angles, primary open-angle glaucoma. The case group consisted of Bronx residents who were diagnosed with FCED who were seen by a single clinician at Montefiore Ophthalmology Department between September 2010 and May 2015. Potential cases were identified using Montefiore’s Clinical Looking Glass (CLG) software via outpatient ICD9 codes and CPT codes for corneal transplants done for FCED . All charts were reviewed to confirm whether the patients met the inclusion criteria of FCDe, and then demographic/clinical data for were collected for all study participants at the time of the initial visit. Presence of anatomic narrow angles and primary open-angle glaucoma were recorded in these patients. Percentages of overall patients with the diagnosis code of anatomic narrow angles or primary open-angle glaucoma were recorded as well.
In a total of 81 FCED patients 21 patients (25.9%) had anatomic narrow angles on the study definition. This was then compared to an incidence of 5.5% of the clinician's total patients. This difference was found to be statistically significant (p < 0.0001). Only 9 patients were also found to have a diagnosis of primary open-angle glaucoma and found not to be significant (p = 0.72) when compared to an incidence of 9.9% of the clinician's total patients. In the demographics we found that all patients were female which was also statistically significant (p = 0.03).
There is an increased incidence of anatomic narrow angles in Fuchs’ Corneal Endothelial Dystrophy patients in the Bronx population. This is consistent with some previous studies that had suggested an association in the past. More research and data is needed to elucidate why this association exists.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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