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Rodrigo Jorge, Felipe Placeres Borges, Murilo Wendeborn Rodrigues, Ingrid U Scott, Rubens C Siqueira; Adaptive optics and its correlation with multimodal imaging and microperimetry in patients with macular capillary loss. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6317.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To correlate adaptive optics photoreceptors arrangement findings with other anatomical and functional exams in patients with macular capillary loss.
Four patients underwent comprehensive ophthalmic evaluation including anatomical (Color fundus pictures, multimodal and adapative optics retinal imaging) and functional ( microperimetry) exams. Cone packing was assessed by AO and confronted with the exams findings.
In ischemic maculas, distribution was uneven and tends to be greater close to vessels. Cone density was lower overall, but specially in less perfused areas on FA. Adaptive optics could recognize photoreceptor damage in normo-reflective OCT- ellipsoid band. In advanced disease, places where AO couldn’t recognize any cell, there were measurable visual function
Adaptive optics showed that the macular cone density was lower than normal even outside the more ischemic areas, even when ellipsoid zone remained preserved on OCT. Cone density can be near normal adjacent to vessels, what could indicate a role of the retinal vasculature in photoreceptor maintenance. Adaptive Optics imaging showed to be more reliable when assessing patients with good visual acuity.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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