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Yosuke Hotta, Takahiro Mizukami, Naomichi Katai; Prevalence of complete posterior vitreous detachment seen on spectral domain optical coherence tomography at each stage of diabetic retinopathy.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6341. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
It is well known that complete posterior vitreous detachment (PVD) prevents the progression of diabetic retinopathy (DR) and the PVD status should be evaluated in all patients with diabetes. There are, however, few reports on the prevalence of PVD at each stage of DR, so we retrospectively analyzed spectral domain optical coherence tomography (SD-OCT) scans to evaluate PVD at each stage of DR.
Medical charts of 265 eyes of control and 284 eyes of diabetic patients met the inclusion criteria of this study who took spectral domain optical coherence tomography between September 2012 and December 2014 were reviewed. We captured images with a 30-degree angle of view and horizontal scan that crossed both the fovea and the disk, and assessed the PVD status. Grading of Retinopathy was done according to the International Clinical Disease Severity Scale for Diabetic Retinopathy.
The mean age was 66.5 years old in control eyes and 67.0 in diabetic eyes, respectively. Of 284 eyes with diabetes, 127 eyes are from no apparent retinopathy (none), 52 eyes are from mild non-proliferative diabetic retinopathy (mild), 58 eyes are from moderate non-proliferative diabetic retinopathy (moderate), 36 eyes are from severe non-proliferative diabetic retinopathy (severe), 11 eyes are from proliferative diabetic retinopathy (PDR: proliferative). The mean HbA1c was 5.6%, 7.2%, 7.7%, 8.1%, 7.4% and 8.0% in control, none, mild, moderate, severe and PDR, respectively. And there were no significant differences in the mean HbA1c among diabetic groups. The complete PVD seen in 82 eyes (64.6%) of none, in 35 eyes (67.3%) of mild, in 25 eyes (43.1%) of moderate, in 12 eyes (33.3%) of severe, in 0 eyes (0%) of PDR and 186 eyes (70.2%) of control. As the severity of the diabetes proceeds from none to proliferation, the prevalence of complete PVD decreased and the P value was 1.0, 1.0, 1.1×10-3, 1.6×10-4 ,2.0×10-5 for none, mild, moderate, severe, and PDR, respectively, when compared with control.
The prevalence of complete PVD in control eyes of this study was similar to previous reports using B-scan ultrasonography and biomicroscope. At each stage of DR, the prevalence of complete PVD differed and in fact decreased with the severity of DR. We concluded that PVD status evaluating by SD-OCT might be valuable to predict the proceeding of DR.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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