Abstract
Purpose :
It has been reported that the preserved inner segment ellipsoid (ISe) and external limiting membrane (ELM) are associated with maintaining visual acuity (VA) in diabetic macular edema (DME) patients. We reported previously that ISe and ELM status once deteriorated after pars plana vitrectomy (PPV), then ELM did not recovered, while IS/OS status recovered and visual acuity (VA) improved after that up to1 year (2013 ARVO). Then we studied the ISe and ELM status of optical coherence tomography (OCT) images in DME for a long period.
Methods :
We retrospectively reviewed the spectral-domain OCT images of 21 eyes from 18 cases with DME who were treated with PPV and evaluated various factors such as the status of ELM and ISe, central retinal thickness (CRT) and VA up to 5 years (Y). We used a percentage disruption to evaluate the status of ELM and ISe.
Results :
logMAR VA was 0.419 at pre-PPV and improved to 0. 242 at 3Y(P<0.001), then to 0.224 at 5Y (P<0.001) after PPV. CRT was 481.8 μm at pre-PPV, decreased to 326 μm at 3Y (P<0.001), then 276.6 μm at 5Y(P<0.001) after PPV. The percentage disruption of ISe was 28.1 % at pre-PPV and decreased gradually to 12.5% at 3Y (P=0.01), then 13.9% at 5Y after PPV (P=0.035). The percentage disruption of ELM was 11.4% at pre-PPV, and decreased to to 8.8% at 3Y (P=0.97), 6.2% at 5Y after PPV (P=0.65).
Conclusions :
VA and ISe improved and CRT decreased significantly at 3Y after PPV, then improved VA and ISe and decreased CRT were maintained up to 5Y.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.