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Haoyu Chen, Xinjian Chen, Xuehui Lu, Weiqi Chen, Honghe Xia, Kangkeng Zheng, Chuang Jin; Retinal microstructural changes on spectral domain optical coherence tomography in endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6378.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the retinal microstructure changes in endophthalmitis and explore the mechanism of vision impairment.
Twenty-five eyes of 25 patients (6 women, 19 men) were included in this study. All patients were diagnosed as endophthalmitis and successfully managed using vitrectomy and/or intravitreal injection of antibiotics. Spectral domain optical coherence tomography (SD-OCT) examination was performed and all patents were followed up for at least 3 months. The OCT images were reviewed and their relationship with best-corrected visual acuity (BCVA) was analyzed.
The microstructural changes identified on SD-OCT were, inner segment ellipsoid (ISe) disruption (44%), atrophy of inner retinal layers (20%), epimacular membrane (12%) and macular edema (8%). The BCVA in the eyes with ISe disruption or inner retinal layers atrophy was lower compared to those without these changes. In multivariable regression analysis, only inner retinal layers atrophy was an independent factor associated with BCVA.
Atrophy of inner retinal layers is an important mechanism for visual impairment in endophthalmitis after successful management.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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