September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Multicenter study of intraocular pressure level in patients with moderate and advanced primary open-angle glaucoma on treatment
Author Affiliations & Notes
  • Ilmira Gazizova
    Northwestern Federal Medical Research Center Almazov, St. Petersburg, Russian Federation
  • Roman Avdeev
    Burdenko State Medical Academy, Voronezh, Voronezh, Russian Federation
  • Aleksander Aleksandrov
    Mandryka Medicine and Clinical Center, Moscow, Russian Federation
  • Aleksander Basinskiy
    Prof. Basynsky Ophthalmology Center Ltd., Orel, Russian Federation
  • Elena Blyum
    5Ophthalmology Hospita, Shymkent, Kazakhstan
  • Andrei Brezhnev
    State Medical University, Kursk, Russian Federation
  • Aisily Galimova
    Russian Eye and Plastic Surgery Center, Ufa, Russian Federation
  • Olesya Gapon’ko
    Mandryka Medicine and Clinical Center, Moscow, Russian Federation
  • Viktor Gar’kavenko
    Voyno-Yasenetsky State Medical University, Krasnoyarsk, Russian Federation
  • Sergei Petrov
    Scientific State Ophthalmology Institute, Moscow, Russian Federation
  • Aleksander Kuroedov
    Mandryka Medicine and Clinical Center, Moscow, Russian Federation
  • Footnotes
    Commercial Relationships   Ilmira Gazizova, None; Roman Avdeev, None; Aleksander Aleksandrov, None; Aleksander Basinskiy, None; Elena Blyum, None; Andrei Brezhnev, None; Aisily Galimova, None; Olesya Gapon’ko, None; Viktor Gar’kavenko, None; Sergei Petrov, None; Aleksander Kuroedov, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6470. doi:
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      Ilmira Gazizova, Roman Avdeev, Aleksander Aleksandrov, Aleksander Basinskiy, Elena Blyum, Andrei Brezhnev, Aisily Galimova, Olesya Gapon’ko, Viktor Gar’kavenko, Sergei Petrov, Aleksander Kuroedov; Multicenter study of intraocular pressure level in patients with moderate and advanced primary open-angle glaucoma on treatment. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6470.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To study the IOP values in patients with primary open-angle glaucoma at the beginning of the study and to correlated them with the disease progression and to determine optimal IOP levels.

Methods : The final protocol included data from 812 right eyes of 637 glaucoma patients and 175 healthy subjects; the latter formed the control group. The mean age of examined patients was 71.8 ± 0.28 years; 72.00 (66.00; 77.00). Mean disease duration in glaucoma patients was 5.41 ± 0.17 years. The following parameters were assessed: visual acuity, clinical refraction, IOP level by Maklakov tonometry, central corneal thickness and IOP-lowering medication use.

Results : . In the age group — between 60 and 69 y.o., the IOP level in patients with advanced glaucoma was significantly higher than in patients with moderate glaucoma and healthy subjects. There was no significant difference in central corneal thickness either between glaucoma patients and healthy subjects (both male and female) or between glaucoma patients with different glaucoma changes. The IOP level was higher in patients treated with non-fixed combination of betablockers and prostaglandins regardless of the disease stage. According to the common standards the IOP level was found to be controlled in 69.93 % of patients with moderate glaucoma and 14.42 % of patients with advanced glaucoma

Conclusions : . The results of the study could be used as clinical guidelines for determination of the optimal IOP range, choosing the optimal IOPlowering medication(s) for starting therapy and during the follow-up in patients with moderate and advanced glaucoma stages.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.


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