A total of 70 patients with APAC were enrolled, of whom 17 were excluded due to poor-quality AS-OCT images, software delineation error, or indeterminate scleral spurs in at least one eye, leaving 53 (75.7%) patients with complete data for the analysis. The mean age of the included patients at presentation was 62.7 ± 8.1 years; 36 (67.9%) were female subjects and 46 (86.8%) were Chinese. The excluded patients did not differ from the included patients in terms of age, sex, and ethnicity.
Table 1 lists the distribution of diagnoses between the affected and fellow eye.
The comparison of biometric and anterior segment parameters between the affected and fellow eye is shown in
Table 2. Fellow eyes were more hyperopic and had steeper corneal curvatures compared with the affected eyes (
P = 0.002 and
P = 0.05, respectively). Although the central corneal thickness was higher in the affected eyes, the mean difference was only 6.6 μm (
P = 0.03, 95% confidence interval [CI]: −12.62, −0.56). After adjusting for pupil diameter, affected eyes had shallower ACD, smaller ACA, ACV, anterior vault, TISA750, AOD750, and ICURV (all
P < 0.05). Axial length, ACW, LV, LT, RLP, central corneal thickness, IT750, and IAREA did not differ between the eyes. Pupil diameter was larger in the affected eye when compared with the fellow eye (
P <0.05).
Table 3 summarizes the age, sex, and PD adjusted results of the univariable and multivariable logistic regression analyses of the association between the biometric/anterior segment parameters and occurrence of APAC. In the multivariable logistic regression, a 0.1-mm decrease in TISA750 (odds ratio [OR]: 24.97, 95% CI: 3.85–161.83), ICURV (OR: 2.63, 95% CI: 1.26–5.52), and ACD (OR: 1.52, 95% CI: 1.20–1.94), was significantly associated with APAC (all
P < 0.05).
Table 4 presents the results of the stepwise multiple linear regression analyses for factors associated with AOD750. In the affected eyes; IT750 was the only significant variable (
P < 0.05), explaining 43% of the variability in AOD750. The model in fellow eyes consisted of two parameters (IT750 and AL) which overall explained 43% of the variability in AOD750. By itself, IT750 explained 24% of the variation in AOD750 in the fellow eyes.